Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation

E Bandala-Sanchez; AJ Roth-Schulze; H Oakey; MAS Penno; NG Bediaga; G Naselli; KM Ngui; AD Smith; D Huang; E Zozaya-Valdes; RL Thomson; JD Brown; PJ Vuillermin; SC Barry; ME Craig; WD Rawlinson; EA Davis; M Harris; G Soldatos; PG Colman; JM Wentworth; A Haynes; G Morahan; RO Sinnott; AT Papenfuss; JJ Couper; LC Harrison

Journal article

Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation

E Bandala-Sanchez, AJ Roth-Schulze, H Oakey, MAS Penno, NG Bediaga, G Naselli, KM Ngui, AD Smith, D Huang, E Zozaya-Valdes, RL Thomson, JD Brown, PJ Vuillermin, SC Barry, ME Craig, WD Rawlinson, EA Davis, M Harris, G Soldatos, PG Colman Show all

Diabetes Research and Clinical Practice | Published : 2022

DOI: 10.1016/j.diabres.2022.109189

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Abstract

Aims: Studies of the gut microbiome have focused on its bacterial composition. We aimed to characterize the gut fungal microbiome (mycobiome) across pregnancy in women with and without type 1 diabetes. Methods: Faecal samples (n = 162) were collected from 70 pregnant women (45 with and 25 without type 1 diabetes) across all trimesters. Fungi were analysed by internal transcribed spacer 1 amplicon sequencing. Markers of intestinal inflammation (faecal calprotectin) and intestinal epithelial integrity (serum intestinal fatty acid binding protein; I-FABP), and serum antibodies to Saccharomyces cerevisiae (ASCA) were measured. Results: Women with type 1 diabetes had decreased fungal alpha divers..

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University of Melbourne Researchers

Maria Bandala Sanchez Author

Peter Colman Author

John Wentworth Author

Grant Morahan Author

Related Projects (1)

CENTRE OF RESEARCH EXCELLENCE FOR THE PROTECTION OF PANCREATIC BETA CELLS

Type 1 diabetes (T1D) is an autoimmune disorder that results in the destruction of the pancreatic beta cells. The overall aim of the CRE is ..

Grants

Awarded by Juvenile Diabetes Research Foundation United States of America

Funding Acknowledgements

This research was supported by JDRF Australia, the recipient of the Commonwealth of Australia grants for Accelerated Research under the Medical Research Future Fund, and with funding from the Leona M. and Harry B. Helmsley Charitable Trust (grant key 3-SRA-2020-966-M-N). In addition, support was provided by The National Health and Medical Research Council of Australia (NHMRC) Centre of Research Excellence for the Protection of Pancreatic Beta Cells (1078106), NHMRC Program Grant (LCH 1150425), and JDRF International (1-SRA-2018-543-S-B). Additional support was provided by the Victorian State Government Operational Infrastructure Support scheme, Diabetes South Australia, and the NHMRC Research Institute Infrastructure Support Scheme. MEC was supported by a NHMRC Practitioner Fellowship (1136735), and LCH by an Investigator Fellowship (1173945).